JQKD 82 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 7676
Selective inhibitor of lysine demethylase 5
Key Product Details
Description
Selective inhibitor of lysine demethylase 5
Product Description
JQKD 82 dihydrochloride is cell-permeable, selective inhibitor of lysine demethylase 5 (KDM5). JQKD 82 does not show activity toward other KDMs; and it has selectivity for KDM5A over other KDM5 isoforms. JQKD 82 causes hypermethylation of H3K4me3, downregulation of MYC targets and RNAPII phosphorylation; it suppresses multiple myeloma cell (MM.1S) growth (IC50 = 0.42 µmol/L). JQKD 82-treated tumors display an increase in H3K4me3 levels and results in a reduction of MYC immuno-staining in NSG mice.Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
573.56
Formula
C27H40N4O5.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2,4-Diisopropoxyphenyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate dihydrochloride
CAS Number
2863635-05-4
InChI Key
LDSXMHKWRLCTDV-UHFFFAOYSA-N
SMILES
CCN(C(CNCC1=CC(C(OC2=C(C=C(C=C2)OC(C)C)OC(C)C)=O)=CC=N1)=O)CCN(C)C.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.68 | 50 |
Preparing Stock Solutions
for JQKD 82 dihydrochloride
The following data is based on the product molecular weight 573.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.49 mL | 17.43 mL | 34.87 mL |
| 2.5 mM | 0.70 mL | 3.49 mL | 6.97 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.49 mL |
| 25 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ohguchi Lysine demethylase 5A is required for MYC driven transcription in multiple myeloma. Blood Cancer Discov. 2021 PMID: 34258103
Product Specific Notices for JQKD 82 dihydrochloride
For research use only
Loading...
Loading...