JQ dS-4
Tocris Bioscience, part of Bio-Techne | Catalog # 8152
BRG1/SMARCA4 Degrader (PROTAC®)
Product Description
JQ dS-4 is a Brahma-related gene 1 (BRG1)/BRM/SMARCA4 Degrader (PROTAC®; DC50 range = 9 - 390 nM in glioma models and cell lines). Comprises a BRG1 inhibitor joined by a linker to a cereblon (CRBN) E3 ligase ligand. Completely degrades BRG1 after 48 and 72 hours in HSJD-DIPG007 and SU-DIPGXIIIP cells and reduces viability of a variety of cancer cell lines including H3K27M glioma, prostate, thyroid and salivary gland.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
719.16
Formula
C37H31ClN8O6
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
3-((4-(3-(2-Chloropyridin-4-yl)ureido)pyridin-2-yl)ethynyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)benzamide
CAS Number
2688882-69-9
PubChem ID
156829976
InChI Key
IIYWQMYQROKRFZ-UHFFFAOYSA-N
SMILES
O=C(NC1=CC(C#CC2=CC=CC(C(NCCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)=C2)=NC=C1)NC6=CC(Cl)=NC=C6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 71.92 | 100 |
Preparing Stock Solutions
for JQ dS-4
The following data is based on the product molecular weight 719.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.39 mL | 6.95 mL | 13.91 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 10 mM | 0.14 mL | 0.70 mL | 1.39 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.28 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Panditharatna BAF complex maintains glioma stem cells in pediatric H3K27M glioma. Cancer Discov. 2022 PMID: 36305736
Product Specific Notices for JQ dS-4
For research use only
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