JP-2-196

Name: JP-2-196
Brand: Tocris Bioscience
SKU: 8046

Tocris Bioscience, part of Bio-Techne | Catalog # 8046

COA / SDS

RNF126 chemical handle

Key Product Details

Description:	RNF126 chemical handle
Chemical Name:	1-(4-Methoxyphenyl)-4-(1-piperazinyl)-2-butene-1,4-dione hydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	310.78

View Full Technical Details for JP-2-196

Technical Data
Citations

Biological Activity for JP-2-196

JP-2-196 is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM. By facilitating E3 ligase recruitment, JP-2-196 induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for JP-2-196

M. Wt	310.78
Formula	C₁₅H₁₈N₂O₃.HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	KITOUXXMDYKXJY-UHDJGPCESA-N
Smiles	O=C(C1=CC=C(C=C1)OC)/C=C/C(N2CCNCC2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for JP-2-196

References are publications that support the biological activity of the product.

Toriki Rational chemical design of molecular glue Degraders. ACS Cent.Sci. 2023 PMID: 37252349