JNJ DGAT2-A

Name: JNJ DGAT2-A
Brand: Tocris Bioscience
SKU: 5853

Tocris Bioscience, part of Bio-Techne | Catalog # 5853

Citations (1)

COA / SDS

DGAT2 inhibitor

Key Product Details

Description:	DGAT2 inhibitor
Chemical Name:	3-Bromo-4-[2-fluoro-4-[[4-oxo-2-[[2-(pyridin-2-yl)ethyl]amino]-1,3-thiazol-5-(4H)ylidene]methyl]phenoxy]benzonitrile
Molecular Weight:	523.38

View Full Technical Details for JNJ DGAT2-A

Technical Data
Citations

Biological Activity for JNJ DGAT2-A

JNJ DGAT2-A is a DGAT2 inhibitor (IC₅₀ = 140 nM). Exhibits >70-fold selectivity for DGAT2 over DGAT1 and MGAT2.

Technical Data for JNJ DGAT2-A

M. Wt	523.38
Formula	C₂₄H₁₆BrFN₄O₂S
Storage	Store at +4°C
CAS Number	1962931-71-0
PubChem ID	101578741
InChi Key	ZFRHAMOJHTZHLT-LPYMAVHISA-N
Smiles	BrC1=C(OC2=C(F)C=C(/C=C3\SC(NCCC4=CC=CC=N4)=NC3=O)C=C2)C=CC(C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ DGAT2-A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	52.34	100

Preparing Stock Solutions for JNJ DGAT2-A

The following data is based on the product molecular weight 523.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.55 mL	19.11 mL
5 mM	0.38 mL	1.91 mL	3.82 mL
10 mM	0.19 mL	0.96 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for JNJ DGAT2-A

References are publications that support the biological activity of the product.

Irshad Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes. J.Lipid Res. 2017 PMID: 27836993
Qi The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 J.Lipid Res. 2012 PMID: 22493088