JNJ 78911118
Tocris Bioscience, part of Bio-Techne | Catalog # 8970
Selective GluN2A antagonist, blood-brain barrier penetrant
Key Product Details
Description
Selective GluN2A antagonist, blood-brain barrier penetrant
Product Description
JNJ 78911118 is a potent, GluN2A-selective NMDA antagonist (IC50 = 44 nM). JNJ 78911118 shows >200-fold selectivity against GluN1/2B, 2C and 2D receptors. In vitro, JNJ 78911118 promotes increases in dendritic complexity and synapse number. In vivo, JNJ 78911118 increases mEPSC frequency in rat cortical neurons, and heart rate and blood pressure in rat toxicological studies. JNJ 78911118 is orally bioavailable and blood-brain barrier penetrant.Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the JNJ 78911118 probe summary on the SGC website.Product Specifications
Molecular Weight
419.82
Formula
C19H16ClF2N5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-(2-(4-Chloropyridin-2-yl)-2,2-difluoroethoxy)-6-methyl-N-(pyridin-3-ylmethyl)pyrazine-2-carboxamide
InChI Key
YPXUKPNZQTWCRR-UHFFFAOYSA-N
SMILES
CC1=C(N=CC(C(NCC2=CN=CC=C2)=O)=N1)OCC(F)(C3=NC=CC(Cl)=C3)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.98 | 100 | |
| Ethanol | 41.98 | 100 |
Preparing Stock Solutions
for JNJ 78911118
The following data is based on the product molecular weight 419.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.91 mL | 23.82 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lord Pharmacological characterisation of JNJ-78911118, a novel, centrally-penetrant, selective GluN2A antagonist. Br.J.Pharmacol. 2025 PMID: 40361296
- Bischoff Design, synthesis, and characterization of GluN2A negative allosteric modulators suitable for in vivo exploration. J.Med.Chem. 2025 PMID: 39960408
Product Specific Notices for JNJ 78911118
For research use only
Loading...
Loading...