JNJ 55511118

Name: JNJ 55511118
Brand: Tocris Bioscience
SKU: 6278

Tocris Bioscience, part of Bio-Techne | Catalog # 6278

Citations (8)

COA / SDS

High affinity and selective negative modulator of AMPA receptors containing TARP-γ8

Key Product Details

Description:	High affinity and selective negative modulator of AMPA receptors containing TARP-γ8
Chemical Name:	5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	328.67

View Full Technical Details for JNJ 55511118

Technical Data
Citations

Biological Activity for JNJ 55511118

JNJ 55511118 is a high affinity and selective negative modulator of AMPA receptors containing TARP-γ8 (K_i = 26 nM). Exhibits <50% binding against a panel of 52 receptors, ion channels and transporters (except 5HT_2B and melatonin receptors 78% and 57%, respectively). Also displays minimal activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2. It reduces alcohol self-administration in a mouse models of chronic drinking. Orally bioavailable and brain penetrant. Anticonvulsant.

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Compound Libraries for JNJ 55511118

JNJ 55511118 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 55511118

M. Wt	328.67
Formula	C₁₄H₈ClF₃N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	2036081-86-2
PubChem ID	122656423
InChi Key	COBXSLRIXGQVGS-UHFFFAOYSA-N
Smiles	ClC1=CC=CC(OC(F)(F)F)=C1C2=CC=C3NC(NC3=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 55511118

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.87	100
	ethanol	32.87	100

Preparing Stock Solutions for JNJ 55511118

The following data is based on the product molecular weight 328.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.21 mL	30.43 mL
5 mM	0.61 mL	3.04 mL	6.09 mL
10 mM	0.30 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for JNJ 55511118

References are publications that support the biological activity of the product.

Witkin A Comment on "Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8". J.Pharmacol.Exp.Ther. 2016 PMID: 27528544
Hoffman Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration. Alcohol Clin.Exp.Res. 2021 PMID: 34086361
Maher Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J.Pharmacol.Exp.Ther. 2016 PMID: 26989142