JNJ 10191584 maleate

Tocris Bioscience, part of Bio-Techne | Catalog # 2441

Selective H4 antagonist; orally active
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Key Product Details

Description

Selective H4 antagonist; orally active

Alternative Names

VUF 6002

View all Histamine H4 Receptor Antagonists »

Product Description

JNJ 10191584 maleate is a highly selective histamine H4 receptor silent antagonist; binds with high affinity to the human H4 receptor (Ki = 26 nM). > 540-fold selective over the H3 receptor (Ki = 14.1 μM). Inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Orally active in vivo.

Product Specifications

Molecular Weight

394.81

Formula

C13H15ClN4O.C4H4O4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate

CAS Number

869497-75-6

PubChem ID

11718163

InChI Key

KOTJFAYEELTYCZ-BTJKTKAUSA-N

SMILES

O=C(O)/C=C\C(O)=O.ClC(C=C3)=CC2=C3N=C(N2)C(N1CCN(C)CC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.74 50

Preparing Stock Solutions for JNJ 10191584 maleate

The following data is based on the product molecular weight 394.81

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.07 mL 25.33 mL 50.66 mL
2.5 mM 1.01 mL 5.07 mL 10.13 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
25 mM 0.10 mL 0.51 mL 1.01 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for JNJ 10191584 maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JNJ 10191584 maleate

For research use only

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