JMV 449

Name: JMV 449
Brand: Tocris Bioscience
SKU: 1998

Tocris Bioscience, part of Bio-Techne | Catalog # 1998

Citations (244)

COA / SDS

Potent neurotensin receptor agonist

Key Product Details

Description:	Potent neurotensin receptor agonist
Purity:	≥95% (HPLC)
Molecular Weight:	746.96

View Full Technical Details for JMV 449

Technical Data
Citations

Biological Activity for JMV 449

JMV 449 is a potent, metabolically stable neurotensin receptor agonist peptide (IC₅₀ = 0.15 nM for inhibition of [¹²⁵I]-NT binding to neonatal mouse brain; EC₅₀ = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

Technical Data for JMV 449

M. Wt	746.96
Formula	C₃₈H₆₆N₈O₇
Single Letter Sequence	KKPYIL (Modifications: Lys-1 - Lys-2 peptide bond replaced with Ψ(CH₂-NH))
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	139026-66-7
PubChem ID	164415
InChi Key	TZCYVPLNMOJUIL-GULBXNHPSA-N
Smiles	[H]N[C@@H](CCCCN)CN[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JMV 449

Solubility

Soluble to 0.8mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for JMV 449

References are publications that support the biological activity of the product.

Dubuc JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 1992 PMID: 1425958
Torup Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 2003 PMID: 14623134
Lugrin Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 1991 PMID: 1812009