JHW 007 hydrochloride

Name: JHW 007 hydrochloride
Brand: Tocris Bioscience
SKU: 4351

Tocris Bioscience, part of Bio-Techne | Catalog # 4351

Citations (2)

COA / SDS

High affinity dopamine uptake inhibitor

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

High affinity dopamine uptake inhibitor

View all Dopamine Transporter Inhibitors »

Product Description

JHW 007 hydrochloride is a dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (K_i = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.

Product Specifications

Molecular Weight

421.95

Formula

C₂₄H₂₉F₂NO.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride

CAS Number

202645-74-7

PubChem ID

71771746

InChI Key

RHYMGBAYGRUKNZ-DHWZJIOFSA-N

SMILES

[H][C@@]12CC[C@@](C[C@H](OC(C4=CC=C(F)C=C4)C3=CC=C(F)C=C3)C2)([H])N1CCCC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.19	100
	Ethanol	42.19	100

Preparing Stock Solutions for JHW 007 hydrochloride

The following data is based on the product molecular weight 421.95

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.85 mL	23.70 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Hiranita Preclinical efficacy of N-substituted benztr. analogs as antagonists of metha. self-administration in rats. J.Pharmacol.Exp.Ther. 2014 PMID: 24194527
Kopajtic DA transporter-dependent and -independent striatal binding of the benztr. analog JHW 007, a cocaine antagonist with low abuse liability. J.Pharmacol.Exp.Ther. 2010 PMID: 20855444
Velaquez-Sanchez The high affinity DA uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization. Eur.Neuropsychopharmacol. 2010 PMID: 20413276
Kristensen SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacol.Rev. 2011 PMID: 21752877