IWP L6
Tocris Bioscience, part of Bio-Techne | Catalog # 4992
Potent PORCN inhibitor
Product Description
IWP L6 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.Product Specifications
Molecular Weight
472.58
Formula
C25H20N4O2S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
CAS Number
1427782-89-5
PubChem ID
71601111
InChI Key
QESQGTFWEQMCMH-UHFFFAOYSA-N
SMILES
O=C1C3=C(CCS3)N=C(SCC(NC4=NC=C(C5=CC=CC=C5)C=C4)=O)N1C2=CC=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.26 | 100 |
Preparing Stock Solutions
for IWP L6
The following data is based on the product molecular weight 472.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.58 mL | 21.16 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.23 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang The development of highly potent inhibitors for Porcupine. J.Med.Chem. 2013 PMID: 23477365
Product Specific Notices for IWP L6
For research use only
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