ITE

Tocris Bioscience, part of Bio-Techne | Catalog # 1803

Endogenous agonist for the transcription factor aryl hydrocarbon receptor
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Key Product Details

Description

Endogenous agonist for the transcription factor aryl hydrocarbon receptor

Alternative Names

Aryl hydrocarbon receptor ligand

View all Aryl Hydrocarbon Receptor Agonists »

Product Description

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.

Product Specifications

Molecular Weight

286.30

Formula

C14H10N2O3S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester

CAS Number

448906-42-1

PubChem ID

4668801

InChI Key

KDDXOGDIPZSCTM-UHFFFAOYSA-N

SMILES

COC(=O)C1=CSC(=N1)C(=O)C1=CNC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.63 100

Preparing Stock Solutions for ITE

The following data is based on the product molecular weight 286.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.46 mL 34.93 mL
5 mM 0.70 mL 3.49 mL 6.99 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.70 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ITE

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ITE

For research use only

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