ITE

Name: ITE
Brand: Tocris Bioscience
SKU: 1803

Tocris Bioscience, part of Bio-Techne | Catalog # 1803

Citations (25)

COA / SDS

Endogenous agonist for the transcription factor aryl hydrocarbon receptor

Key Product Details

Description:	Endogenous agonist for the transcription factor aryl hydrocarbon receptor
Alternative Names:	Aryl hydrocarbon receptor ligand
Chemical Name:	2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	286.3

View Full Technical Details for ITE

Technical Data
Citations

Biological Activity for ITE

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (K_i = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.

Compound Libraries for ITE

ITE is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for ITE

M. Wt	286.3
Formula	C₁₄H₁₀N₂O₃S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	448906-42-1
PubChem ID	4668801
InChi Key	KDDXOGDIPZSCTM-UHFFFAOYSA-N
Smiles	COC(=O)C1=CSC(=N1)C(=O)C1=CNC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ITE

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.63	100

Preparing Stock Solutions for ITE

The following data is based on the product molecular weight 286.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.49 mL	17.46 mL	34.93 mL
5 mM	0.70 mL	3.49 mL	6.99 mL
10 mM	0.35 mL	1.75 mL	3.49 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References for ITE

References are publications that support the biological activity of the product.

Wang An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett. 2013 PMID: 23851185
Lehmann The aryl hydrocarbon receptor ligand ITE inhibits TGF beta 1-induced human myofibroblast differentiation. Am.J.Pathol. 2011 PMID: 21406171
Cheng Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat.Commun. 2015 PMID: 26059097
Song A ligand for the aryl hydrocarbon receptor isolated from lung. Proc.Natl.Acad.Sci.U.S.A. 2002 PMID: 12409613

ITE