IT1t dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4596
Potent CXCR4 antagonist
Product Description
IT1t dihydrochloride is a potent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).Product Specifications
Molecular Weight
479.57
Formula
C21H34N4S2.2HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride
CAS Number
1092776-63-0
PubChem ID
25178351
InChI Key
HFXJOXOIINQOEB-UHFFFAOYSA-N
SMILES
CC1(C)CN(C(CS/C(NC4CCCCC4)=N/C3CCCCC3)=CS2)C2=N1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 47.96 | 100 | |
| DMSO | 4.8 | 10 |
Preparing Stock Solutions
for IT1t dihydrochloride
The following data is based on the product molecular weight 479.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.43 mL | 20.85 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.17 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thoma Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J.Med.Chem. 2008 PMID: 19053768
Product Specific Notices for IT1t dihydrochloride
For research use only
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