IT1t dihydrochloride

Name: IT1t dihydrochloride
Brand: Tocris Bioscience
SKU: 4596

Tocris Bioscience, part of Bio-Techne | Catalog # 4596

Citations (15)

COA / SDS

Potent CXCR4 antagonist

Key Product Details

Description:	Potent CXCR4 antagonist
Chemical Name:	N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	479.57

View Full Technical Details for IT1t dihydrochloride

Technical Data
Citations

Biological Activity for IT1t dihydrochloride

IT1t dihydrochloride is a potent CXCR4 antagonist (IC₅₀ = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC₅₀ = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).

Technical Data for IT1t dihydrochloride

M. Wt	479.57
Formula	C₂₁H₃₄N₄S₂.2HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1092776-63-0
PubChem ID	25178351
InChi Key	HFXJOXOIINQOEB-UHFFFAOYSA-N
Smiles	CC1(C)CN(C(CS/C(NC4CCCCC4)=N/C3CCCCC3)=CS2)C2=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IT1t dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.8	10
	water	47.96	100

Preparing Stock Solutions for IT1t dihydrochloride

The following data is based on the product molecular weight 479.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.43 mL	20.85 mL
5 mM	0.42 mL	2.09 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Reconstitution Calculator

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References for IT1t dihydrochloride

References are publications that support the biological activity of the product.

Thoma Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J.Med.Chem. 2008 PMID: 19053768