IRAK3 Degrader 23
Tocris Bioscience, part of Bio-Techne | Catalog # 7983
IRAK3 Degrader (PROTAC®
Product Description
IRAK3 Degrader 23 is a potent and selective IRAK3 Degrader (PROTAC®; DC50 = 2 nM; Dmax = 98% in THP1 cells and primary macrophages), requires CRBN and IRAK3 binding for Degrader activity. Also inhibits CDK11, CDK8, TRKC and GSG2 (IC50 values are 16 nM, 36 nM, 100 nM and 110 nM respectively).PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
878.09
Formula
C47H63N11O6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(2,6-Dioxo-3-piperidyl)-5-[4-[2-[1-[4-[4-[cis-4-[(5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]-piperazin-1-yl]-4-oxo-butanoyl]-4-piperidyl]ethyl]piperazin-1-yl]-isoindoline-1,3-dione
CAS Number
2712600-00-3
PubChem ID
162366970
InChI Key
ZUODKONSNNHSAJ-AMLBMYBGSA-N
SMILES
O=C1C2=CC(N3CCN(CC3)CCC4CCN(CC4)C(CCC(N5CCN([C@@H]6CC[C@@H](CC6)NC7=NC=NN8C7=C(C(C)C)C=C8)CC5)=O)=O)=CC=C2C(N1C9C(NC(CC9)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 87.81 | 100 |
Preparing Stock Solutions
for IRAK3 Degrader 23
The following data is based on the product molecular weight 878.09
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.14 mL | 5.69 mL | 11.39 mL |
| 5 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 10 mM | 0.11 mL | 0.57 mL | 1.14 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.23 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Degorce Discovery of proteolysis-targeting chimera molecules that selectively degrade the IRAK3 pseudokinase. J.Med.Chem. 2020 PMID: 32803978
Product Specific Notices for IRAK3 Degrader 23
For research use only
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