Ipsapirone
Tocris Bioscience, part of Bio-Techne | Catalog # 1869
Selective 5-HT1A agonist
Key Product Details
Description
Selective 5-HT1A agonist
Alternative Names
TVX Q 7821
Product Description
Ipsapirone is a selective 5-HT1A receptor agonist (Ki = 10 nM). Anxiolytic in vivo.Product Specifications
Molecular Weight
401.48
Formula
C19H23N5O3S
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxide
CAS Number
95847-70-4
PubChem ID
56971
InChI Key
TZJUVVIWVWFLCD-UHFFFAOYSA-N
SMILES
O=C1N(CCCCN2CCN(CC2)C2=NC=CC=N2)S(=O)(=O)C2=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.01 | 10 |
Preparing Stock Solutions
for Ipsapirone
The following data is based on the product molecular weight 401.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.91 mL | 124.54 mL | 249.08 mL |
| 0.5 mM | 4.98 mL | 24.91 mL | 49.82 mL |
| 1 mM | 2.49 mL | 12.45 mL | 24.91 mL |
| 5 mM | 0.50 mL | 2.49 mL | 4.98 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Glaser and Traber Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites. Naunyn-Schmied.Arch.Pharmacol.
- Traber Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821. Brain Res.Bull. 1984 PMID: 6541079
- Maj Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and DArgic functions. J.Neural.Transm. 1987 PMID: 2889795
Product Specific Notices for Ipsapirone
For research use only
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