IPA 3

Name: IPA 3
Brand: Tocris Bioscience
SKU: 3622

Tocris Bioscience, part of Bio-Techne | Catalog # 3622

Citations (100)

COA / SDS

Group I PAK inhibitor

Key Product Details

Description:	Group I PAK inhibitor
Chemical Name:	1,1'-Dithiodi-2-naphthtol
Purity:	≥96% (HPLC)
Molecular Weight:	350.45

View Full Technical Details for IPA 3

Technical Data
Citations

Biological Activity for IPA 3

IPA 3 is a group I p21-activated kinase (PAK) inhibitor (IC₅₀ = 2.5 μM at PAK1). Targets the autoregulatory mechanism and promotes the inactive conformation of PAKs. Inhibits PAK1-mediated signaling in vivo; potential anti-tumor agent.

Negative Control also available.

Technical Data for IPA 3

M. Wt	350.45
Formula	C₂₀H₁₄O₂S₂
Storage	Store at -20°C
Purity	≥96% (HPLC)
CAS Number	42521-82-4
PubChem ID	521106
InChi Key	RFAXLXKIAKIUDT-UHFFFAOYSA-N
Smiles	OC2=C(SSC3=C(O)C=CC4=C3C=CC=C4)C1=CC=CC=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IPA 3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.28	75

Preparing Stock Solutions for IPA 3

The following data is based on the product molecular weight 350.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.80 mL	19.02 mL	38.05 mL
3.75 mM	0.76 mL	3.80 mL	7.61 mL
7.5 mM	0.38 mL	1.90 mL	3.80 mL
37.5 mM	0.08 mL	0.38 mL	0.76 mL

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Reconstitution Calculator

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References for IPA 3

References are publications that support the biological activity of the product.

Wang P21-activated kinase inhibitors FRAX486 and IPA3: inhibition of prostate stromal cell growth and effects on smooth muscle contraction in the human prostate. PLoS One 2016 PMID: 27071060
Viaud and Peterson An allosteric kinase inhibitor binds the p21-activated kinase (Pak) autoregulatory domain covalently. Mol.Cancer Ther. 2009 PMID: 19723886
Deacon An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem.Biol. 2008 PMID: 18420139
Takahashi and Suzuki Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/op18 to Pak1-WAVE2-kinesin complex. Cell.Signal. 2009 PMID: 19162178
Kumar p21-activated kinases in cancer. Nat.Rev.Cancer 2006 PMID: 16723992