Indorenate hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2399
5-HT1A, 5-HT1B and 5-HT2C agonist
Discontinued Product
2399 has been discontinued.
View all 5-HT1B Receptor Agonists products.
Key Product Details
Description
5-HT1A, 5-HT1B and 5-HT2C agonist
Alternative Names
TR 3369
Product Description
5-HT receptor agonist with high affinity for 5-HT1A receptors (pKd = 7.8) and lower affinity for 5-HT1B and 5-HT2C receptors (pKd values are 5.44 and 6.49 respectively). Possesses anti-hypertensive, anxiolytic and anorectic activity in vivo.Product Specifications
Molecular Weight
284.74
Formula
C13H16N2O3.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
α-(Aminomethyl)-5-methoxy-1H-indole-3-acetic acid methyl ester hydrochloride
CAS Number
72318-55-9
SMILES
NCC(C(OC)=O)C2=CNC1=CC=C(OC)C=C12.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.47 | 100 | |
| DMSO | 28.47 | 100 |
Preparing Stock Solutions
for Indorenate hydrochloride
The following data is based on the product molecular weight 284.74
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.51 mL | 17.56 mL | 35.12 mL |
| 5 mM | 0.70 mL | 3.51 mL | 7.02 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.51 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sanchez and Velazquez-Martinez Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats. J.Psychopharmacol. 2001 PMID: 11277605
- Miranda Further evidence that the discriminative stimulus properties of indorenate are mediated by 5-HT1A/1B/2C receptors. Pharmacol.Biochem.Behav. 2003 PMID: 12479957
- Velazquez-Martinez Discriminative stimulus properties of indorenate, a serotonin agonist. J.Psychiatry Neurosci. 1999 PMID: 10212554
Product Specific Notices for Indorenate hydrochloride
For research use only
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