Indatraline hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1588
Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake
Key Product Details
Description
Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake
Alternative Names
Lu 19-005
Product Description
Indatraline hydrochloride is a potent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenaline (NET) (Ki values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.Product Specifications
Molecular Weight
328.67
Formula
C16H15Cl2N.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(1R,3S)-rel-3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride
CAS Number
96850-13-4
PubChem ID
10314472
InChI Key
QICQDZXGZOVTEF-MELYUZJYSA-N
SMILES
ClC(C=C3)=C(Cl)C=[C@@]3[C@H]2C1=CC=CC=C1[C@H](NC)C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.29 | 10 with gentle warming | |
| DMSO | 32.87 | 100 |
Preparing Stock Solutions
for Indatraline hydrochloride
The following data is based on the product molecular weight 328.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.04 mL | 15.21 mL | 30.43 mL |
| 5 mM | 0.61 mL | 3.04 mL | 6.09 mL |
| 10 mM | 0.30 mL | 1.52 mL | 3.04 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hyttel and Larsen Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of DA, noradrenaline and serotonin. J.Neurochem. 1985 PMID: 2580950
- Negus Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. J.Pharmacol.Exp.Ther. 1999 PMID: 10490887
- Gu Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J.Med.Chem. 2000 PMID: 11123996
Product Specific Notices for Indatraline hydrochloride
For research use only
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