IN 1130

Tocris Bioscience, part of Bio-Techne | Catalog # 6016

COA / SDS

Potent and selective inhibitor of TGF-βRI

Key Product Details

Description:	Potent and selective inhibitor of TGF-βRI
Chemical Name:	3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	420.47

View Full Technical Details for IN 1130

Technical Data
Citations

Biological Activity for IN 1130

IN 1130 is a potent and selective inhibitor of TGF-β type I receptor (ALK5). Inhibits Smad-2 phosphorylation (IC₅₀ = 5.3 nM). Exhibits selectivity over a panel of 27 serine/ threonine and tyrosine kinases including P38α. Attenuates TGFβ/Smad signaling, cell migration, invasion, lung metastasis and increases survival of mice in 4TI in vivo models. Suppresses renal fibrosis in obstructive nephropathy in vivo models.

Technical Data for IN 1130

M. Wt	420.47
Formula	C25H20N6O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	868612-83-3
PubChem ID	11676119
InChi Key	RYKSGWSKILPDDY-UHFFFAOYSA-N
Smiles	CC1=NC(C2=C(C3=CC4=C(N=CC=N4)C=C3)NC(CC5=CC(C(N)=O)=CC=C5)=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IN 1130

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.05	100
	1eq. HCl	42.05	100

Preparing Stock Solutions for IN 1130

The following data is based on the product molecular weight 420.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.89 mL	23.78 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for IN 1130

References are publications that support the biological activity of the product.

Lee Effect of IN-1130, a small molecule inhibitor of transforming growth factor-beta type I receptor/AVNreceptor-like kinase-5, on prostate cancer cells. J.Urol. 2008 PMID: 18951571
Park An novel inhibitor of TGF-beta type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition. Cancer Lett. 2014 PMID: 24887560
Moon IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy. Kidney Int. 2006 PMID: 16929250