Imetit dihydrobromide

Name: Imetit dihydrobromide
Brand: Tocris Bioscience
SKU: 0729

Tocris Bioscience, part of Bio-Techne | Catalog # 0729

Citations (9)

COA / SDS

Standard H3 and H4 agonist (H3 > H4)

Key Product Details

Description:	Standard H₃ and H₄ agonist (H₃ > H₄)
Chemical Name:	5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	332.06

View Full Technical Details for Imetit dihydrobromide

Technical Data
Citations

Biological Activity for Imetit dihydrobromide

Imetit dihydrobromide is an an extremely potent, high affinity agonist at H₃ and H₄ receptors (K_i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC₅₀ of 25 nM. Centrally active following systemic administration.

Technical Data for Imetit dihydrobromide

M. Wt	332.06
Formula	C₆H₁₀N₄S.2HBr
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	32385-58-3
PubChem ID	11957573
InChi Key	DOBOYMKCRRLTRF-UHFFFAOYSA-N
Smiles	Br.Br.NC(=N)SCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Imetit dihydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	33.21	100

Preparing Stock Solutions for Imetit dihydrobromide

The following data is based on the product molecular weight 332.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.06 mL	30.12 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for Imetit dihydrobromide

References are publications that support the biological activity of the product.

Garbarg S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H₃ receptor agonist. J.Pharmacol.Exp.Ther. 1992 PMID: 1383495
Ling Histamine H₄ receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br.J.Pharmacol. 2004 PMID: 15131002
Farzin and Attarzadeh Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 2000 PMID: 10980276