iMAC2

Name: iMAC2
Brand: Tocris Bioscience
SKU: 3794

Tocris Bioscience, part of Bio-Techne | Catalog # 3794

COA / SDS

Suppressor of mitochondrial apoptosis

Discontinued Product

3794 has been discontinued. View all Additional Apoptosis-related Compounds products.

Key Product Details

Description:	Suppressor of mitochondrial apoptosis
Chemical Name:	3,6-Dibromo-9-[2-fluoro-3-(1-piperazinyl)propyl]-9H-carbazole dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	542.11

View Full Technical Details for iMAC2

Technical Data
Citations

Biological Activity for iMAC2

iMAC2 is an inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC₅₀ = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC₅₀ = 0.68 μM).

Technical Data for iMAC2

M. Wt	542.11
Formula	C₁₉H₂₀Br₂FN₃.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	335166-00-2
PubChem ID	90488878
InChi Key	JWCVUOLQOHIRML-UHFFFAOYSA-N
Smiles	BrC(C=C3)=CC1=C3N(CC(F)CN4CCNCC4)C2=C1C=C(Br)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for iMAC2

References are publications that support the biological activity of the product.

Peixoto MAC inhibitors suppress mitochondrial apoptosis. Biochem.J. 2009 PMID: 19691447
Bombrun 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 2003 PMID: 14521400

iMAC2

Tocris Bioscience, part of Bio-Techne | Catalog # 3794

Key Product Details

Biological Activity for iMAC2

Technical Data for iMAC2

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for iMAC2

Product Documents for iMAC2

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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