IKK 16
Tocris Bioscience, part of Bio-Techne | Catalog # 2539
Selective inhibitor of IKK
Product Description
IKK 16 is a selective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50 values are 1.0, 0.5, 0.3 and 0.3 μM respectively). Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.Product Specifications
Molecular Weight
520.09
Formula
C28H29N5OS.HCl
Storage
Desiccate at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride
CAS Number
1186195-62-9
PubChem ID
56972179
InChI Key
XFVDIVQCZWDBCW-UHFFFAOYSA-N
SMILES
Cl.O=C(N1CCC(CC1)N1CCCC1)C1=CC=C(NC2=NC=CC(=N2)C2=CC3=CC=CC=C3S2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26 | 50 | |
| DMSO | 26 | 50 |
Preparing Stock Solutions
for IKK 16
The following data is based on the product molecular weight 520.09
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.85 mL | 19.23 mL | 38.45 mL |
| 2.5 mM | 0.77 mL | 3.85 mL | 7.69 mL |
| 5 mM | 0.38 mL | 1.92 mL | 3.85 mL |
| 25 mM | 0.08 mL | 0.38 mL | 0.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Waelchli Design and preparation of 2-benzoamido-pyrimidines as inhibitors of IKK. Bioorg.Med.Chem.Lett. 2006 PMID: 16236504
Product Specific Notices for IKK 16
For research use only
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