iFSP1

Name: iFSP1
Brand: Tocris Bioscience
SKU: 7162

Tocris Bioscience, part of Bio-Techne | Catalog # 7162

COA / SDS

Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer

Key Product Details

Description:	Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer
Chemical Name:	1-Amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	323.36

View Full Technical Details for iFSP1

Technical Data
Citations

Biological Activity for iFSP1

iFSP1 is a ferroptosis inducer. Inhibits ferroptosis suppressor protein 1 (FSP1) and induces ferroptosis in GPX4 knockout cells. Sensitizes tumor cells to RSL3 (Cat. No. 6118) -induced ferroptosis.

Technical Data for iFSP1

M. Wt	323.36
Formula	C₂₀H₁₃N₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	150651-39-1
PubChem ID	699043
InChi Key	FNESYDFRCQEEKA-UHFFFAOYSA-N
Smiles	CC1=CC=C(C2=C(C#N)C3=NC4=CC=CC=C4N3C(N)=C2C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for iFSP1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.47	20

Preparing Stock Solutions for iFSP1

The following data is based on the product molecular weight 323.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	15.46 mL	77.31 mL	154.63 mL
1 mM	3.09 mL	15.46 mL	30.93 mL
2 mM	1.55 mL	7.73 mL	15.46 mL
10 mM	0.31 mL	1.55 mL	3.09 mL

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References for iFSP1

References are publications that support the biological activity of the product.

Bersuker The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 2019 PMID: 31634900