ICA 110381

Tocris Bioscience, part of Bio-Techne | Catalog # 4950

KV7.2/7.3 activator; displays anticonvulsant properties
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Key Product Details

Description

KV7.2/7.3 activator; displays anticonvulsant properties

View all Voltage-gated Potassium Channel Activators »

Product Description

ICA 110381 is a KV7.2/7.3 activator (EC50 = 0.38 μM). Decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures.

Product Specifications

Molecular Weight

267.11

Formula

C12H8Cl2N2O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-Chloro-N-(6-chloro-3-pyridinyl)benzamide

CAS Number

325457-99-6

PubChem ID

4314115

InChI Key

FOYOGIUAMYSVIT-UHFFFAOYSA-N

SMILES

O=C(NC2=CC=C(Cl)N=C2)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.71 100
Ethanol 5.34 20

Preparing Stock Solutions for ICA 110381

The following data is based on the product molecular weight 267.11

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.72 mL 37.44 mL
5 mM 0.75 mL 3.74 mL 7.49 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ICA 110381

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ICA 110381

For research use only

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