ICA 069673

Tocris Bioscience, part of Bio-Techne | Catalog # 4305

KV7.2/KV7.3 channel opener
Catalog #
Availability
Size / Price
Qty
4305/5
4305/25
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Description

KV7.2/KV7.3 channel opener

View all Voltage-gated Potassium Channel Activators »

Product Description

ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

Product Specifications

Molecular Weight

269.63

Formula

C11H6ClF2N3O

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

CAS Number

582323-16-8

PubChem ID

10149311

InChI Key

IIBSHMFXVWTQSJ-UHFFFAOYSA-N

SMILES

ClC1=NC=C(NC(C2=CC(F)=C(F)C=C2)=O)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.96 100
Ethanol 6.74 25

Preparing Stock Solutions for ICA 069673

The following data is based on the product molecular weight 269.63

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.54 mL 37.09 mL
5 mM 0.74 mL 3.71 mL 7.42 mL
10 mM 0.37 mL 1.85 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for ICA 069673

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ICA 069673

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.