IC 87201

Name: IC 87201
Brand: Tocris Bioscience
SKU: 6226

Tocris Bioscience, part of Bio-Techne | Catalog # 6226

COA / SDS

nNOS-PSD95 protein-protein interaction inhibitor; also antinociceptive and antidepressant

Discontinued Product

6226 has been discontinued. View all Additional NMDA Receptor Compounds products.

Key Product Details

Description:	nNOS-PSD95 protein-protein interaction inhibitor; also antinociceptive and antidepressant
Chemical Name:	2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol
Purity:	≥99% (HPLC)
Molecular Weight:	309.15

View Full Technical Details for IC 87201

Technical Data
Citations

Biological Activity for IC 87201

IC 87201 is an inhibits binding of the NMDA receptor postsynaptic density protein 95 kDa (PSD95) to nNOS (EC₅₀ = 23.94 μM), while not affecting the PSD95-ErbB4 interaction. Inhibits glutamate-induced cell death in cultured cortical neurons. Exhibits antinociceptive effects in inflammatory pain models in vivo. Also exhibits antidepressant-like activitiy in animal models.

Technical Data for IC 87201

M. Wt	309.15
Formula	C₁₃H₁₀Cl₂N₄O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	866927-10-8
PubChem ID	11771269
InChi Key	QEHVTUCLCBXQIC-UHFFFAOYSA-N
Smiles	OC1=C(C=C(C=C1Cl)Cl)CNC2=CC=C3N=NNC3=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for IC 87201

References are publications that support the biological activity of the product.

Lee Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics. Neuropharmacology. 2015 PMID: 26071110
Florio Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents. Br.J.Pharmacol. 2009 PMID: 19732061
Doucet Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice. Neuropsychopharmacology. 2013 PMID: 23446451

IC 87201

Tocris Bioscience, part of Bio-Techne | Catalog # 6226

Key Product Details

Biological Activity for IC 87201

Technical Data for IC 87201

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for IC 87201

Product Documents for IC 87201

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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