Ibudilast

Product Description

Ibudilast is a phosphodiesterase inhibitor (IC₅₀ values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Also inhibits leukotriene D4 (LTD4) and histamine-induced inositol monophosphate (IP1) formation in guinea pig lung with no direct effect on LTD4 receptors. Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Solubility

Preparing Stock Solutions for Ibudilast

The following data is based on the product molecular weight 230.31

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.34 mL	21.71 mL	43.42 mL
5 mM	0.87 mL	4.34 mL	8.68 mL
10 mM	0.43 mL	2.17 mL	4.34 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Etoh Inhibition by ibudilast of leukotriene D4-induced formation of inositol phosphates in guinea-pig lung. Br.J.Pharmacol. 1990 PMID: 2117981
• Nishino KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis. Jpn.J.Pharmacol. 1983 PMID: 6193303
• Souness Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone. Br.J.Pharmacol. 1994 PMID: 8032594
• Kishi Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovasc.Drug Rev. 2001 PMID: 11607039