IB-MECA
Tocris Bioscience, part of Bio-Techne | Catalog # 1066
A3 selective agonist
Key Product Details
Description
A3 selective agonist
Alternative Names
CF 101,Piclidenoson
Product Description
IB-MECA is a potent and selective A3 adenosine receptor agonist (Ki values are 1.1, 54 and 56 nM for A3, A1 and A2A receptors respectively). Cardioprotective, reduces infarct size upon reperfusion in rats.Licensing Information
Sold with the permission of the NIH, US Patent 08/091,109Product Specifications
Molecular Weight
510.29
Formula
C18H19IN6O4
Storage
Desiccate at +4°C
Purity
≥97% (HPLC)
Chemical Name
1-Deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide
CAS Number
152918-18-8
PubChem ID
123683
InChI Key
HUJXGQILHAUCCV-MOROJQBDSA-N
SMILES
IC1=CC=CC(CNC2=NC=NC3=C2N=CN3[C@@H]4O[C@H]([C@@](NC)=O)[C@@H](O)[C@H]4O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25 |
Preparing Stock Solutions
for IB-MECA
The following data is based on the product molecular weight 510.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 7.84 mL | 39.19 mL | 78.39 mL |
| 1.25 mM | 1.57 mL | 7.84 mL | 15.68 mL |
| 2.5 mM | 0.78 mL | 3.92 mL | 7.84 mL |
| 12.5 mM | 0.16 mL | 0.78 mL | 1.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Klotz Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832
- Park N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3β. J.Pharmacol.Exp.Ther. 2006 PMID: 16611852
- Gallo-Rodriguez Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists. J.Med.Chem. 1994 PMID: 8126704
Product Specific Notices for IB-MECA
For research use only
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