I 432

Tocris Bioscience, part of Bio-Techne | Catalog # 7292

TMPRSS2 Inhibitor
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Key Product Details

Description

TMPRSS2 Inhibitor

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Product Description

I 432 is a TMPRSS2 (transmembrane serine proteinase 2) inhibitor (Ki =0.9 nM). It blocks influenza virus propagation in airway epithelial cells. In IPEC-J2 pig jejunal epithelial cells, I 432 (50 μM) inhibits TMPRSS2 without affecting cell viability after 48 h treatment.

Product Specifications

Molecular Weight

830.62

Formula

C29H33Cl2N5O3S.2CF3CO2H

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[(2S)-3-[4-(2-Aminoethyl)-1-piperidinyl]-2-[[(2',4'-dichloro[1,1'-biphenyl]-3-yl)sulfonyl]amino]-3-oxopropyl]benzenecarboximidamide ditrifluoroacetate

CAS Number

1268874-09-4

InChI Key

HCTPOLRWOSFUBB-LPCSYZHESA-N

SMILES

NCCC1CCN(C([C@@H](NS(=O)(C2=CC=CC(C3=C(C=C(C=C3)Cl)Cl)=C2)=O)CC4=CC(C(N)=N)=CC=C4)=O)CC1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 83.06 100
Ethanol 83.06 100

Preparing Stock Solutions for I 432

The following data is based on the product molecular weight 830.62

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.20 mL 6.02 mL 12.04 mL
5 mM 0.24 mL 1.20 mL 2.41 mL
10 mM 0.12 mL 0.60 mL 1.20 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for I 432

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for I 432

For research use only

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