HS 024
Tocris Bioscience, part of Bio-Techne | Catalog # 1832
Highly potent MC4 receptor antagonist
Key Product Details
Description
Highly potent MC4 receptor antagonist
Product Description
HS 024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.Product Specifications
Molecular Weight
1266.50
Formula
C58H79N19O10S2
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
212370-59-7
PubChem ID
25081552
InChI Key
PUOCNCOPVAOMDE-LQXMKOPKSA-N
SMILES
CCCC[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 0.5mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Jonsson Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 2002 PMID: 12065241
- Kask Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 1998 PMID: 9832440
- Jonsson Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 2001 PMID: 11726778
Product Specific Notices for HS 024
For research use only
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