HS 014
Tocris Bioscience, part of Bio-Techne | Catalog # 1831
Selective MC4 receptor antagonist
Key Product Details
Description
Selective MC4 receptor antagonist
Product Description
HS 014 is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.Product Specifications
Molecular Weight
1563.77
Formula
C71H94N20O17S2
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
207678-81-7
PubChem ID
24821295
InChI Key
BRGDPINZISNYJL-VMAVSDBDSA-N
SMILES
CC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Schioth Discovery of novel melanocortin4 receptor selective MSH analogues. Br.J.Pharmacol. 1998 PMID: 9630346
- Whitaker and Reye Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration. Neuropharmacology 2008 PMID: 18082228
- Bellasio Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 2003 PMID: 14660013
Product Specific Notices for HS 014
For research use only
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