HC 030031
Tocris Bioscience, part of Bio-Techne | Catalog # 2896
Selective TRPA1 blocker
Product Description
HC 030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC50 values are 6.2 and 5.3 μM respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or NaV1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo.Product Specifications
Molecular Weight
355.39
Formula
C18H21N5O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
CAS Number
349085-38-7
PubChem ID
1150897
InChI Key
HEQDZPHDVAOBLN-UHFFFAOYSA-N
SMILES
O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)C)C=C3)=O)N(C)C(N1C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.54 | 100 |
Preparing Stock Solutions
for HC 030031
The following data is based on the product molecular weight 355.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.81 mL | 14.07 mL | 28.14 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.63 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.81 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- McNamara TRPA1 mediates formalin-induced pain. Proc.Natl.Acad.Sci.USA 2007 PMID: 17686976
- Taylor-Clark Prostaglandin-induced activation of nociceptive neurons via direct interactions with TRPA1. Mol.Pharmacol. 2008 PMID: 18000030
Product Specific Notices for HC 030031
For research use only
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