HBX 41108

Tocris Bioscience, part of Bio-Techne | Catalog # 4285

Selective USP7 inhibitor
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Key Product Details

Description

Selective USP7 inhibitor

View all Deubiquitinating Enzyme Inhibitors »

Product Description

HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

Licensing Information

Sold for research use only under patent license from Hybrigenics S.A.

Product Specifications

Molecular Weight

266.64

Formula

C13H3ClN4O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

CAS Number

924296-39-9

PubChem ID

16065773

InChI Key

BIGPXXAUSQLTQR-UHFFFAOYSA-N

SMILES

O=C2C1=CC(Cl)=CC=C1C3=C2N=C(C#N)C(C#N)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.66 100

Preparing Stock Solutions for HBX 41108

The following data is based on the product molecular weight 266.64

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.75 mL 37.50 mL
5 mM 0.75 mL 3.75 mL 7.50 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for HBX 41108

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HBX 41108

For research use only

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