HA 130

Name: HA 130
Brand: Tocris Bioscience
SKU: 4196

Tocris Bioscience, part of Bio-Techne | Catalog # 4196

Citations (7)

COA / SDS

Potent and selective autotaxin inhibitor

Key Product Details

Description:	Potent and selective autotaxin inhibitor
Chemical Name:	B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid
Purity:	≥98% (HPLC)
Molecular Weight:	463.29

View Full Technical Details for HA 130

Technical Data
Citations

Biological Activity for HA 130

HA 130 is a potent and selective autotaxin inhibitor (IC₅₀ = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.

Compound Libraries for HA 130

HA 130 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HA 130

M. Wt	463.29
Formula	C₂₄H₁₉BFNO₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1229652-21-4
PubChem ID	46911532
InChi Key	VTNKMYWFWQTEHE-XKZIYDEJSA-N
Smiles	FC1=CC=C(CN3C(/C(SC3=O)=C/C2=CC=C(OCC4=CC(B(O)O)=CC=C4)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HA 130

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.33	100

Preparing Stock Solutions for HA 130

The following data is based on the product molecular weight 463.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.79 mL	21.58 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for HA 130

References are publications that support the biological activity of the product.

Albers Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc.Natl.Acad.Sci.USA 2010 PMID: 20360563
Albers Discovery and optimization of boronic acid based inhibitors of autotaxin. J.Med.Chem. 2010 PMID: 20536182