GW 501516

Name: GW 501516
Brand: Tocris Bioscience
SKU: 5674

Tocris Bioscience, part of Bio-Techne | Catalog # 5674

Citations (15)

COA / SDS

Potent and selective PPARδ agonist

Key Product Details

Description:	Potent and selective PPARδ agonist
Chemical Name:	2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	453.5

View Full Technical Details for GW 501516

Technical Data
Citations

Biological Activity for GW 501516

GW 501516 is a potent and selective PPARδ agonist (EC₅₀ = 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.

Technical Data for GW 501516

M. Wt	453.5
Formula	C₂₁H₁₈F₃NO₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	317318-70-0
PubChem ID	9803963
InChi Key	YDBLKRPLXZNVNB-UHFFFAOYSA-N
Smiles	CC1=CC(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)=CC=C1OCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 501516

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.35	100
	ethanol	22.68	50

Preparing Stock Solutions for GW 501516

The following data is based on the product molecular weight 453.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.03 mL	22.05 mL
5 mM	0.44 mL	2.21 mL	4.41 mL
10 mM	0.22 mL	1.10 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for GW 501516

References are publications that support the biological activity of the product.

Ito Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science 2016 PMID: 27738012
Oliver A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc.Natl.Acad.Sci.USA. 2001 PMID: 11309497