GW 441756
Tocris Bioscience, part of Bio-Techne | Catalog # 2238
Potent, selective TrkA inhibitor
Product Description
GW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline.Product Specifications
Molecular Weight
275.31
Formula
C17H13N3O
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
CAS Number
504433-23-2
PubChem ID
16219401
InChI Key
NXNQLECPAXXYTR-UHFFFAOYSA-N
SMILES
CN1C=C(C=C2C(=O)NC3=CC=CN=C23)C2=C1C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.13 | 15 |
Preparing Stock Solutions
for GW 441756
The following data is based on the product molecular weight 275.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.15 mM | 24.22 mL | 121.08 mL | 242.15 mL |
| 0.75 mM | 4.84 mL | 24.22 mL | 48.43 mL |
| 1.5 mM | 2.42 mL | 12.11 mL | 24.22 mL |
| 7.5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wood Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg.Med.Chem.Lett. 2004 PMID: 15013000
Product Specific Notices for GW 441756
For research use only
Loading...
Loading...