GW 441756

Name: GW 441756
Brand: Tocris Bioscience
SKU: 2238

Tocris Bioscience, part of Bio-Techne | Catalog # 2238

Citations (37)

COA / SDS

Potent, selective TrkA inhibitor

Key Product Details

Description:	Potent, selective TrkA inhibitor
Chemical Name:	1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Purity:	≥99% (HPLC)
Molecular Weight:	275.31

View Full Technical Details for GW 441756

Technical Data
Citations

Biological Activity for GW 441756

GW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC₅₀ = 2 nM). Displays > 100-fold selectivity over a range of other kinases.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data for GW 441756

M. Wt	275.31
Formula	C₁₇H₁₃N₃O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	504433-23-2
PubChem ID	16219401
InChi Key	NXNQLECPAXXYTR-UHFFFAOYSA-N
Smiles	CN1C=C(C=C2C(=O)NC3=CC=CN=C23)C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 441756

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.13	15

Preparing Stock Solutions for GW 441756

The following data is based on the product molecular weight 275.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.15 mM	24.22 mL	121.08 mL	242.15 mL
0.75 mM	4.84 mL	24.22 mL	48.43 mL
1.5 mM	2.42 mL	12.11 mL	24.22 mL
7.5 mM	0.48 mL	2.42 mL	4.84 mL

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References for GW 441756

References are publications that support the biological activity of the product.

Wood Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg.Med.Chem.Lett. 2004 PMID: 15013000