Guanfacine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1030
α2A agonist
Product Description
Guanfacine hydrochloride is a selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors.Product Specifications
Molecular Weight
282.56
Formula
C9H9Cl2N3O.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
[(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride
CAS Number
29110-48-3
PubChem ID
71401
InChI Key
DGFYECXYGUIODH-UHFFFAOYSA-N
SMILES
Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.26 | 100 | |
| DMSO | 28.26 | 100 |
Preparing Stock Solutions
for Guanfacine hydrochloride
The following data is based on the product molecular weight 282.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.70 mL | 35.39 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Uhlen and Wikberg Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanf. is an α2A -selective compound. Eur.J.Pharmacol. 1991 PMID: 1666366
- Intengan and Smyth Alpha-2a/d adrenoceptor subtype stimulation by guanf. increases osmolar clearance. J.Pharmacol.Exp.Ther. 1997 PMID: 9103479
Product Specific Notices for Guanfacine hydrochloride
For research use only
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