GSK 9027
Tocris Bioscience, part of Bio-Techne | Catalog # 4116
Glucocorticoid receptor agonist
Key Product Details
Description
Glucocorticoid receptor agonist
Product Description
GSK 9027 is a glucocorticoid receptor agonist (pIC50 = 8). Inhibits production of the proinflammatory mediator IL-6 in vivo.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline.Product Specifications
Molecular Weight
525.52
Formula
C27H19F4N3O2S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-[4-[1-(4-Fluorophenyl)-1H-indazol-5-yl-3-(trifluoromethyl)phenyl]benzenesulfonamide
CAS Number
1229096-88-1
PubChem ID
24882669
InChI Key
DXBJGDVBQPEMOB-UHFFFAOYSA-N
SMILES
FC(C=C3)=CC=C3N2C1=CC=C(C4=C(C(F)(F)F)C=C(NS(CC5=CC=CC=C5)(=O)=O)C=C4)C=C1C=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.55 | 100 |
Preparing Stock Solutions
for GSK 9027
The following data is based on the product molecular weight 525.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.90 mL | 9.51 mL | 19.03 mL |
| 5 mM | 0.38 mL | 1.90 mL | 3.81 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.90 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yates Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists. J.Med.Chem. 2010 PMID: 20469868
Product Specific Notices for GSK 9027
For research use only
Loading...
Loading...