GSK 2334470
Tocris Bioscience, part of Bio-Techne | Catalog # 4143
Highly potent, selective PDPK1 (PDK1) inhibitor
Key Product Details
Description
Highly potent, selective PDPK1 (PDK1) inhibitor
Product Description
GSK 2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDPK1) inhibitor (IC50 ~ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice.Licensing Information
Sold for research purposes only under agreement from GlaxoSmithKlineExternal Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK 2334470 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
462.59
Formula
C25H34N8O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide
CAS Number
1227911-45-6
PubChem ID
46215815
InChI Key
QLPHOXTXAKOFMU-WBVHZDCISA-N
SMILES
C[C@H]1N(C3=NC(NC)=NC(C4=CC(NN=C5N)=C5C=C4)=C3)C[C@@H]([C@](NC2CCCCC2)=O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.26 | 100 | |
| Ethanol | 46.26 | 100 |
Preparing Stock Solutions
for GSK 2334470
The following data is based on the product molecular weight 462.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.16 mL | 10.81 mL | 21.62 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.32 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Scortegagna Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of BrafV600E::Pten(-/-) melanoma. Oncogene 2014 PMID: 24037523
- Najafov Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem.J. 2011 PMID: 21087210
Product Specific Notices for GSK 2334470
For research use only
Loading...
Loading...