GSK 2256098
Tocris Bioscience, part of Bio-Techne | Catalog # 7786
Potent focal adhesion kinase (FAK) inhibitor
Key Product Details
Description
Potent focal adhesion kinase (FAK) inhibitor
Product Description
GSK 2256098 is a potent, reversible and ATP-competitive focal adhesion kinase (FAK) inhibitor (IC50 values are 8.5 nM, 12 nM and 15 nM in U87MG, A549 and OVCAR8 cell lines respectively). Inhibits Y397 phosphorylation and motility, growth and survival of pancreatic ductal adenocarcinoma cells.Product Specifications
Molecular Weight
414.89
Formula
C20H23ClN6O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[5-Chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxybenzamide
CAS Number
1224887-10-8
PubChem ID
46214930
InChI Key
BVAHPPKGOOJSPU-UHFFFAOYSA-N
SMILES
O=C(C1=C(NC2=CC(NC3=CC(C)=NN3C(C)C)=NC=C2Cl)C=CC=C1)NOC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.49 | 100 | |
| Ethanol | 20.74 | 50 |
Preparing Stock Solutions
for GSK 2256098
The following data is based on the product molecular weight 414.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.05 mL | 24.10 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.82 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Cell Cycle 2014 PMID: 25486573
Product Specific Notices for GSK 2256098
For research use only
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