GSK 2033
Tocris Bioscience, part of Bio-Techne | Catalog # 5694
Potent LXR antagonist
Product Description
GSK 2033 is a potent LXR antagonist (pIC50 = 7.5). Enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells. Cell permeable.Product Specifications
Molecular Weight
591.66
Formula
C29H28F3NO5S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide
CAS Number
1221277-90-2
PubChem ID
46203250
InChI Key
PSOXOVKYGWBTPB-UHFFFAOYSA-N
SMILES
CC1=CC(C)=CC(C)=C1S(N(CC2=CC=C(C(F)(F)F)O2)CC(C=C3)=CC=C3C4=CC(S(C)(=O)=O)=CC=C4)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.83 | 20 |
Preparing Stock Solutions
for GSK 2033
The following data is based on the product molecular weight 591.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.45 mL | 42.25 mL | 84.51 mL |
| 1 mM | 1.69 mL | 8.45 mL | 16.90 mL |
| 2 mM | 0.85 mL | 4.23 mL | 8.45 mL |
| 10 mM | 0.17 mL | 0.85 mL | 1.69 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Solt LXR-mediated inhibition of CD4+ T helper cells. PLoS ONE 2012 PMID: 23029557
- Zuercher Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J.Med.Chem. 2010 PMID: 20345102
Product Specific Notices for GSK 2033
For research use only
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