GSK 143
Tocris Bioscience, part of Bio-Techne | Catalog # 6362
Syk inhibitor
Product Description
GSK 143 is a spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines.Product Specifications
Molecular Weight
415.32
Formula
C17H22N6O2.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[(3R,4R)-3-Aminotetrahydro-2H-pyran-4-yl]amino]-4-[(4-methylphenyl)amino]-5-pyrimidinecarboxamide dihydrochloride
CAS Number
2341796-81-2
PubChem ID
46865656
InChI Key
InChIKey=UEHPBSLIDBDMCZ-WICJZZOFSA-N
SMILES
CC1=CC=C(C=C1)NC2=NC(N[C@@H]3CCOC[C@@H]3N)=NC=C2C(N)=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 41.53 | 100 | |
| DMSO | 41.53 | 100 |
Preparing Stock Solutions
for GSK 143
The following data is based on the product molecular weight 415.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.04 mL | 24.08 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.82 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Varghese Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. Br.J.Haematol 2018 PMID: 28770560
- Liddle Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg.Med.Chem.Lett. 2011 PMID: 21903390
Product Specific Notices for GSK 143
For research use only
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