GSK 0660

Name: GSK 0660
Brand: Tocris Bioscience
SKU: 3433

Tocris Bioscience, part of Bio-Techne | Catalog # 3433

Citations (51)

COA / SDS

Selective PPARδ antagonist

Key Product Details

Description:	Selective PPARδ antagonist
Chemical Name:	3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	418.49

View Full Technical Details for GSK 0660

Technical Data
Citations

Biological Activity for GSK 0660

GSK 0660 is a selective PPARδ antagonist (IC₅₀ values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ respectively). Exhibits inverse agonist effects when administered by itself.

Compound Libraries for GSK 0660

GSK 0660 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GSK 0660

M. Wt	418.49
Formula	C₁₉H₁₈N₂O₅S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1014691-61-2
PubChem ID	46233311
InChi Key	NDFKBGWLUHKMFY-UHFFFAOYSA-N
Smiles	O=S(NC1=C(OC)C=C(NC3=CC=CC=C3)C=C1)(C2=C(C(OC)=O)SC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 0660

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.85	100
	ethanol	4.18	10

Preparing Stock Solutions for GSK 0660

The following data is based on the product molecular weight 418.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.95 mL	23.90 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.19 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for GSK 0660

References are publications that support the biological activity of the product.

Wang PPAR-δ in vascular pathophysiology. PPAR Res. 2008 PMID: 19132133
Bishop-Bailey and Swales The role of PPARs in the endothelium: Implications for cancer therapy. PPAR Res. 2008 PMID: 19043612
Shearer Identification and characterization of a selective peroxisome proliferator-activated receptor β/δ (NR1C2) antagonist. Mol.Endocrinol. 2008 PMID: 17975020