GRP (porcine)

Name: GRP (porcine)
Brand: Tocris Bioscience
SKU: 1788

Tocris Bioscience, part of Bio-Techne | Catalog # 1788

COA / SDS

Endogenous GRP receptor agonist

Discontinued Product

1788 has been discontinued. View all Bombesin Receptor Agonists products.

Key Product Details

Description:	Endogenous GRP receptor agonist
Alternative Names:	Gastrin-releasing peptide (porcine)
Molecular Weight:	2805.31

View Full Technical Details for GRP (porcine)

Technical Data
Citations

Biological Activity for GRP (porcine)

GRP (porcine) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.

Technical Data for GRP (porcine)

M. Wt	2805.31
Formula	C₁₂₆H₁₉₈N₃₈O₃₁S₂
Single Letter Sequence	APVSVGGGTVLAKMYPRGNHWAVGHLM (Modifications: Met-27 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	74815-57-9
PubChem ID	16132336
InChi Key	GLCDCQPXUJKYKQ-GZDVRPNBSA-N
Smiles	[H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GRP (porcine)

References are publications that support the biological activity of the product.

Woodruff Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 1996 PMID: 8602736
Schjoldager Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction. Am.J.Physiol. 1991 PMID: 1708207
Shumyatsky Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 2002 PMID: 12526815
Dudai Neurobiology: Fear thou not. Nature 2003 PMID: 12540884

GRP (porcine)

Tocris Bioscience, part of Bio-Techne | Catalog # 1788

Key Product Details

Biological Activity for GRP (porcine)

Technical Data for GRP (porcine)

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for GRP (porcine)

Product Documents for GRP (porcine)

COA

Certificate of Analysis

SDS

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