GRI 977143
Tocris Bioscience, part of Bio-Techne | Catalog # 4779
Selective LPA2 receptor non-lipid agonist
Key Product Details
Description
Selective LPA2 receptor non-lipid agonist
Product Description
GRI 977143 is a selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 μM). Does not activate other LPA GPCRs at concentrations up to 10 μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.Product Specifications
Molecular Weight
391.44
Formula
C22H17NO4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
CAS Number
325850-81-5
PubChem ID
3114900
InChI Key
GMVZUCHUOYUMLL-UHFFFAOYSA-N
SMILES
O=C(C2=CC=CC3=CC=CC(C4=O)=C23)N4CCCSC1=CC=CC=C1C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.14 | 100 |
Preparing Stock Solutions
for GRI 977143
The following data is based on the product molecular weight 391.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.77 mL | 25.55 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kiss Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. Biochim.Biophys.Acta 2013 PMID: 23127512
- Kiss Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol.Pharmacol. 2012 PMID: 22968304
Product Specific Notices for GRI 977143
For research use only
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