GR 89696 fumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 1483
Subtype-selective κ agonist
Key Product Details
Description
Subtype-selective κ agonist
Product Description
GR 89696 fumarate is a highly potent and selective κ-opioid agonist (IC50 = 0.04 nM) that may be selective for the putative κ2 receptor. Anti-nociceptive and neuroprotective in vivo.Product Specifications
Molecular Weight
530.40
Formula
C19H25Cl2N3O3.C4H4O4
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate
CAS Number
126766-32-3
PubChem ID
6442840
InChI Key
ABTNETSDXZBJTE-WLHGVMLRSA-N
SMILES
[H]OC(=O)\C=C\C(=O)O[H].COC(=O)N1CCN(C(CN2CCCC2)C1)C(=O)CC1=CC=C(Cl)C(Cl)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 13.26 | 25 with gentle warming | |
| DMSO | 53.04 | 100 |
Preparing Stock Solutions
for GR 89696 fumarate
The following data is based on the product molecular weight 530.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.89 mL | 9.43 mL | 18.85 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.89 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Butelman GR89,696: a potent κ-opioid agonist with subtype selectivity in rhesus monkeys. J.Pharmacol.Exp.Ther. 2001 PMID: 11504802
- Naylor A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines. J.Med.Chem. 1993 PMID: 8393489
- Birch Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist. Br.J.Pharmacol. 1991 PMID: 1657267
Product Specific Notices for GR 89696 fumarate
For research use only
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