GR 89696 fumarate

Name: GR 89696 fumarate
Brand: Tocris Bioscience
SKU: 1483

Catalog # 1483 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

Subtype-selective κ agonist

Key Product Details

Description:	Subtype-selective κ agonist
Chemical Name:	4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate
Purity:	≥99% (HPLC)
Molecular Weight:	530.4

View Full Technical Details for GR 89696 fumarate

Technical Data
Citations / Reviews

Biological Activity for GR 89696 fumarate

GR 89696 fumarate is a highly potent and selective κ-opioid agonist (IC₅₀ = 0.04 nM) that may be selective for the putative κ₂ receptor. Anti-nociceptive and neuroprotective in vivo.

Compound Libraries for GR 89696 fumarate

GR 89696 fumarate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GR 89696 fumarate

M. Wt	530.4
Formula	C₁₉H₂₅Cl₂N₃O₃.C₄H₄O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	126766-32-3
PubChem ID	6442840
InChi Key	ABTNETSDXZBJTE-WLHGVMLRSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].COC(=O)N1CCN(C(CN2CCCC2)C1)C(=O)CC1=CC=C(Cl)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GR 89696 fumarate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	13.26	25 with gentle warming
	DMSO	53.04	100

Preparing Stock Solutions for GR 89696 fumarate

The following data is based on the product molecular weight 530.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.89 mL	9.43 mL	18.85 mL
5 mM	0.38 mL	1.89 mL	3.77 mL
10 mM	0.19 mL	0.94 mL	1.89 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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Reconstitution Calculator

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References for GR 89696 fumarate

References are publications that support the biological activity of the product.

Butelman GR89,696: a potent κ-opioid agonist with subtype selectivity in rhesus monkeys. J.Pharmacol.Exp.Ther. 2001 PMID: 11504802
Naylor A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines. J.Med.Chem. 1993 PMID: 8393489
Birch Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist. Br.J.Pharmacol. 1991 PMID: 1657267

Citations for GR 89696 fumarate

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