GR 55562 dihydrochloride

Name: GR 55562 dihydrochloride
Brand: Tocris Bioscience
SKU: 1054
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1054

(1)

Citations (12)

COA / SDS

5-HT1B antagonist

Key Product Details

Description:	5-HT_1B antagonist
Chemical Name:	3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	448.39

View Full Technical Details for GR 55562 dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for GR 55562 dihydrochloride

GR 55562 dihydrochloride is a selective competitive 5-HT_1B (5-HT_1Dβ) silent antagonist with pK_B values of 7.3 and 6.3 for human cloned 5-HT_1B and 5-HT_1D receptors respectively and only weak binding at a number of other 5-HT subtypes.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for GR 55562 dihydrochloride

M. Wt	448.39
Formula	C₂₃H₂₅N₃O₂.2HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	159533-25-2
PubChem ID	56972159
InChi Key	KBKWJHYQFQONBJ-UHFFFAOYSA-N
Smiles	Cl.Cl.CN(C)CCCC1=CC(=CC=C1O)C(=O)NC1=CC=C(C=C1)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GR 55562 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for GR 55562 dihydrochloride

The following data is based on the product molecular weight 448.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.15 mL	22.30 mL
5 mM	0.45 mL	2.23 mL	4.46 mL
10 mM	0.22 mL	1.12 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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Reconstitution Calculator

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References for GR 55562 dihydrochloride

References are publications that support the biological activity of the product.

Walsh The activity of 5-HT_1D receptor ligands at cloned human 5-HT_1Dα and 5-HT_1Dβ receptors. Eur.J.Pharmacol. 1995 PMID: 8666030
Connor Use of GR55562, a selective 5-HT_1D antagonist, to investigate 5-HT_1D receptor subtypes mediating cerebral vasoconstriction. Cephalalgia
MacLean Evidence for 5-HT₁-like receptor-mediated vasoconstriction in human pulmonary artery. Br.J.Pharmacol. 1996 PMID: 8886409