GPR52 Comp-43
Tocris Bioscience, part of Bio-Techne | Catalog # 7445
GPR52 receptor antagonist
Key Product Details
Description
GPR52 receptor antagonist
Product Description
GPR52 Comp-43 is a GPR52 receptor antagonist (IC50 = 0.63 μM). The use of GPR52 Comp-43 in animal models of Huntington's Disease leads to degradation and reduction of soluble and aggregated mutant huntingtin protein in the striatum. It also reduces neuronal loss, promotes neuronal survival and improves motor functions in vivo. GPR52 Comp-43 is active in vitro and brain penetrant.Product Specifications
Molecular Weight
242.34
Formula
C15H14OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2E)-5-Phenyl-1-(2-thienyl)-2-penten-1-one
CAS Number
1239987-91-7
PubChem ID
156588927
InChI Key
XUIAIACHIPOOHR-BJMVGYQFSA-N
SMILES
O=C(C1=CC=CS1)/C=C/CCC2=CC=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.23 | 100 | |
| Ethanol | 24.23 | 100 |
Preparing Stock Solutions
for GPR52 Comp-43
The following data is based on the product molecular weight 242.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.13 mL | 20.63 mL | 41.26 mL |
| 5 mM | 0.83 mL | 4.13 mL | 8.25 mL |
| 10 mM | 0.41 mL | 2.06 mL | 4.13 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.83 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Komatsu Discovery of the first druggable GPR52 antagonist to treat Huntington's disease. J.Med.Chem. 2021 PMID: 33443413
- Wang GPR52 antagonist reduces huntingtin levels and ameliorates Huntington's disease-related phenotypes. J.Med.Chem. 2021 PMID: 33185430
Product Specific Notices for GPR52 Comp-43
For research use only
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