GoSlo SR 5-69
Tocris Bioscience, part of Bio-Techne | Catalog # 5814
KCa1.1 (BK) channel activator
Key Product Details
Description
KCa1.1 (BK) channel activator
Product Description
GoSlo SR 5-69 is a BK channel activator (EC50 = 251 nM). Shifts the voltage required for half maximal negatively (DV1/2 = -104 mV).Product Specifications
Molecular Weight
470.47
Formula
C24H19N2NaO5S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
Sodium 1-Amino-9,10-dioxo-4-((5,6,7,8-tetrahydronaphthalen-2-yl)amino)-9,10-dihydroanthracene-2-sulfonate
CAS Number
1363419-31-1
PubChem ID
56944133
InChI Key
JOJJZTFRBZWSBX-UHFFFAOYSA-M
SMILES
NC1=C2C(C3=CC=CC=C3C(C2=C(C=C1S(=O)([O-])=O)NC4=CC=C5CCCCC5=C4)=O)=O.[Na+]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.05 | 100 |
Preparing Stock Solutions
for GoSlo SR 5-69
The following data is based on the product molecular weight 470.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.63 mL | 21.26 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.25 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schewe A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science 2019 PMID: 30792303
- Roy Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. Eur.J.Med.Chem. 2014 PMID: 24561672
Product Specific Notices for GoSlo SR 5-69
For research use only
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