Goserelin acetate

Name: Goserelin acetate
Brand: Tocris Bioscience
SKU: 3592

Tocris Bioscience, part of Bio-Techne | Catalog # 3592

COA / SDS

GnRH receptor agonist

Discontinued Product

3592 has been discontinued. View all GnRH Agonist products.

Key Product Details

Description:	GnRH receptor agonist
Molecular Weight:	1269.42

View Full Technical Details for Goserelin acetate

Technical Data
Citations

Biological Activity for Goserelin acetate

Goserelin acetate is a synthetic gonadotropin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotropin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers.

Technical Data for Goserelin acetate

M. Wt	1269.42
Formula	C₅₉H₈₄N₁₈O₁₄
Single Letter Sequence	XHWSYSLRP (Modifications: X = Pyr, Ser-4 = t-Bu-Ser, Pro-9 = terminal NH-NH-CO-NH2)
Storage	Desiccate at -20°C
CAS Number	145781-92-6
PubChem ID	90488862
InChi Key	BLCLNMBMMGCOAS-JFBCNRKLSA-N
Smiles	[H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O)C(=O)C1CCC(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Goserelin acetate

References are publications that support the biological activity of the product.

Chatzaki The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res. 1996 PMID: 8616851
Chrisp and Goa Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions. Drugs
Dondi Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 1994 PMID: 8033142

Product Documents for Goserelin acetate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Goserelin acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov