Glycine
Tocris Bioscience, part of Bio-Techne | Catalog # 0219
Endogenous potentiator of NMDA receptors
Key Product Details
Description
Endogenous potentiator of NMDA receptors
Product Description
One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors.Product Specifications
Molecular Weight
75.07
Formula
C2H5NO2
Storage
Store at RT
Chemical Name
Aminoethanoic acid
CAS Number
56-40-6
PubChem ID
750
InChI Key
DHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
NCC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
for Glycine
The following data is based on the product molecular weight 75.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 13.32 mL | 66.60 mL | 133.21 mL |
| 5 mM | 2.66 mL | 13.32 mL | 26.64 mL |
| 10 mM | 1.33 mL | 6.66 mL | 13.32 mL |
| 50 mM | 0.27 mL | 1.33 mL | 2.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Johnson and Ascher Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature
- Kuhse The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr.Opin.Neurobiol. 1995 PMID: 7850154
- Ascher and Johnson The NMDA receptor, its channel and its modulation by glycine. The NMDA Receptor (2nd edition). Eds. G.L.Collingr
- Betz Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends Neurosci. 1991 PMID: 1722365
Product Specific Notices for Glycine
For research use only
Loading...
Loading...
Loading...